It would appear that Gregory Warnes has ported it to R and the package
`haplo.score' can be downloaded from CRAN (http://cran.r-project.org).
-roger
_______________________________
UCLA Department of Statistics
rpeng at stat.ucla.edu
http://www.stat.ucla.edu/~rpeng
On Fri, 14 Feb 2003, Shona Livingstone wrote:
> <color><param>0100,0100,0100</param>Dear All,
>
> I wish to use a suite of programs called "haplo.score" first
written in S plus by
> Rowland et al of the Mayo clinic (details given below). Unfortunately, I do
not
> have S plus available to me at the moment
>
>
> Has anyone written the equivalent for R?
>
>
> Any pointers will be appreciated, bearing in mind that I am new to R.
>
>
> Thank you for your help
>
> Shona Livingstone
>
> Epidemiology and Public Health, UCL
>
>
> *****************************
>
>
<bold><FontFamily><param>Arial</param><smaller>haplo.score
>
> <italic>Score Tests for Association of Traits with Haplotypes when
>
> Linkage Phase is Ambiguous
>
> </italic></bold><FontFamily><param>Times New
Roman</param>Charles M. Rowland, David E. Tines, and Daniel J. Schaid
>
> Mayo Clinic
>
> Rochester, MN
>
> E-mail contact: rowland at mayo.edu
>
> <bold><FontFamily><param>Arial</param>I
>
> [</bold><FontFamily><param>Times New Roman</param>A
suite of S-PLUS routines, referred to as "haplo.score", can be used to
compute score
> statistics to
>
> test associations between haplotypes and a wide variety of traits,
including binary,
> ordinal,
>
> quantitative, and Poisson. These methods assume that all subjects are
unrelated and that
> haplotypes
>
> are ambiguous (due to unknown linkage phase of the genetic markers). The
methods
> provide
>
> several different global and haplotype-specific tests for association, as
well as provide
> adjustment
>
> for non-genetic covariates and computation of simulation p-values (which
may be
> needed for
>
> sparse data). Details on the background and theory of the score statistics
can be found
> in the
>
> following reference:
>
> Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA. Score tests for
>
> association of traits with haplotypes when linkage phase is ambiguous.
American J
>
> Human Genetics, February, 2002.]
>
>
> <nofill>
>
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>