Hi,
a collegue has send me an excel sheet with some plasma values, and now he wants
to know the AUC steady state.
I took a look at the CRAN taskviews, and came up with PK, PKtools, ...
The AUC calculation, no problem with that, but how do I calculate the steady
state?
One way of thinking was with the aid of multiple t-test, to find where we
couldn't find difference between the different measuring points, and take
this as steady state, but I'm not sure that this is the right way.
As I'm not home in the pharmacokinetic world, I was hoping someone with some
more experience can shed some light on this (altough for me) dark material.
Kind Regards
Bart
PS: Here some example data:
dat<- structure(list(Sample = c(1L, 1L, 1L, 1L, 1L, 1L, 2L, 2L, 2L,
2L, 2L, 2L), tijd = c(12L, 36L, 60L, 84L, 108L, 132L, 12L, 36L,
60L, 84L, 108L, 132L), conc = c(0.621518061431366, 0.87531564366726,
0.916311538568891, 0.880947260781843, 0.852202744098934, 0.218909173985895,
1.22305496551836, 1.30075841227452, 0.995918019674464, 1.33214099618361,
1.42613784296527, 0.290928921761672)), .Names = c("Sample",
"Time",
"conc"), row.names = c(NA, -12L), class = "data.frame")
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