wine users - Aug 2011 - Re: Direct rendering disabled - apparently common on 64bit

Did you installed "ia32libs" (don't remember the exact name) ?
If you've installed nvidia driver from .run, did it asked you for 32bits GLX
libraries installation ?

The "trick" here is to also have 32bits libraries and GLX driver to
make it work.

Thanks, but I already solved it that way back in April ;)