R help - Oct 2008 - group sequential analysis - stopping for futility

Hello - 

I am wondering if anyone has written some R code to calculate futility 
bounds for a group sequential analysis of clinical trials data.  The 
library ldbounds has a function 'bounds'  which calculates the 
effectiveness stopping bounds for various spending functions,  but it does 
not appear to do the same for futility (sometimes called the 'inner 
wedge').

Thanks for any assistance!

-Alice

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Em Ter, 2008-10-28 ?s 08:30 -0700, Alice.Pressman at nsmtp.kp.org
escreveu:
> Hello - 
> 
> I am wondering if anyone has written some R code to calculate futility 
> bounds for a group sequential analysis of clinical trials data.  The 
> library ldbounds has a function 'bounds'  which calculates the 
> effectiveness stopping bounds for various spending functions,  but it does 
> not appear to do the same for futility (sometimes called the 'inner 
> wedge').
> 
> Thanks for any assistance!
> 
> -Alice

Hi alice, 

I have interest in develop this code with you .

Do you have a paper about this?
-- 
Bernardo Rangel Tura, M.D,MPH,Ph.D
National Institute of Cardiology
Brazil