search for: ldbounds

Hello - I am wondering if anyone has written some R code to calculate futility bounds for a group sequential analysis of clinical trials data. The library ldbounds has a function 'bounds' which calculates the effectiveness stopping bounds for various spending functions, but it does not appear to do the same for futility (sometimes called the 'inner wedge'). Thanks for any assistance! -Alice NOTICE TO RECIPIENT: If you are not the inte...

...I don’t yet have a good understanding of the various approaches to sequential clinical trials designs, I thought that the gsDesign package seemed very impressive. I also understand that there are several other R packages that relate to sequential clinical trials designs, such as AGSDest , GroupSeq, ldbounds, MChtest, PwrGSD, and Seqmon. Some of these seem fairly comprehensive while others seem to focus on a single approach.   My questions center on the adequacy of SPLUS Seqtrial and the R Packages. I was wondering if there is anyone out there who would be familiar enough with these to comment on thei...

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