Alice.Pressman at nsmtp.kp.org
2008-Oct-28 15:30 UTC
[R] group sequential analysis - stopping for futility
Hello - I am wondering if anyone has written some R code to calculate futility bounds for a group sequential analysis of clinical trials data. The library ldbounds has a function 'bounds' which calculates the effectiveness stopping bounds for various spending functions, but it does not appear to do the same for futility (sometimes called the 'inner wedge'). Thanks for any assistance! -Alice NOTICE TO RECIPIENT: If you are not the intended recipi...{{dropped:10}}
Bernardo Rangel Tura
2008-Oct-30 08:51 UTC
[R] group sequential analysis - stopping for futility
Em Ter, 2008-10-28 ?s 08:30 -0700, Alice.Pressman at nsmtp.kp.org escreveu:> Hello - > > I am wondering if anyone has written some R code to calculate futility > bounds for a group sequential analysis of clinical trials data. The > library ldbounds has a function 'bounds' which calculates the > effectiveness stopping bounds for various spending functions, but it does > not appear to do the same for futility (sometimes called the 'inner > wedge'). > > Thanks for any assistance! > > -AliceHi alice, I have interest in develop this code with you . Do you have a paper about this? -- Bernardo Rangel Tura, M.D,MPH,Ph.D National Institute of Cardiology Brazil
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