We have posted a major new version 2.0 of the samr package for large scale significance testing, especially for gene expression data. This new version handles RNA-seq data, using the new method described in http://www-stat.stanford.edu/~tibs/ftp/Li_Tibs.pdf We have also added simple interface functions SAM and SAMseq. Comments (and bug reports) welcome! -- I get so much email that I might not reply to an incoming email, just because it got lost. So don't hesitate to email me again. The probability of a reply should increase. Prof. Robert Tibshirani ?Depts of Health Research and Policy, and Statistics ?Stanford Univ ?Stanford CA 94305 tibs at stanford.edu http://www-stat.stanford.edu/~tibs