Dear R-help, I'd like ask for your opinion on choosing the "right" strategy for a particular dataset. We conducted 24-hour electric field measurements on 90 subjects. They are grouped by job (2 categories) and location (3 categories). There are four exposure metrics assigned to each subject. An excerpt from the data: n job location M OA UE all 0 job1 dist_200 0.297 0.072 0.171 0.297 1 job1 dist_200 0.083 0.529 0.066 0.529 2 job1 dist_200 0.105 0.145 1.072 1.072 3 job1 dist_200 0.096 0.431 0.099 0.431 4 job1 dist_200 0.137 0.077 0.092 0.137 5 job1 dist_20 NA 0.296 0.107 0.296 6 job1 dist_200 NA 1.595 0.293 1.595 7 job1 dist_20 NA 0.085 0.076 0.085 8 job1 dist_20 NA 2.120 0.319 2.120 9 job1 dist_20 NA 0.881 NA 0.881 10 job1 dist_0 NA 0.221 NA 0.221 80 job2 dist_20 0.800 0.342 1.482 1.482 81 job2 dist_20 NA 0.521 0.050 0.521 82 job2 dist_200 NA 0.497 0.502 0.502 83 job2 dist_200 NA 2.777 NA 2.777 84 job2 dist_20 NA 0.127 0.050 0.127 85 job2 dist_200 NA 2.508 0.423 2.508 86 job2 dist_200 0.216 0.350 2.782 2.782 87 job2 dist_200 NA 2.777 1.996 2.777 88 job2 dist_200 2.348 0.890 2.777 2.777 89 job2 dist_200 NA 0.488 NA 0.488 I'd like to know whether the differences between the group means are significant. Is a pairwise t-test (for location, and a simple t-test for job) appropriate in this case? data = read.table("data.txt", header=T, nrows=90) attach(data) res1 = pairwise.t.test(all, location, p.adj="bonf") print(res1) res2 = pairwise.t.test(M, location, p.adj="bonf") print(res2) res3 = pairwise.t.test(OA, location, p.adj="bonf") print(res3) res4 = pairwise.t.test(UE, location, p.adj="bonf") print(res4) res1 = t.test(all~job) print(res1) res2 = t.test(M~job) print(res2) res3 = t.test(OA~job) print(res3) res4 = t.test(UE~job) print(res4) I'd also like to compare the four exposure metrics - how to do that? One potential problem is that the distribution is not normal for any of the exposure metrics: it's close to lognormal. (In fact, it's even worse than that: the measuring instrument has a relatively high lower detection limit, and all off-scale low points are marked as the det. limit. In other words, non-detects are censored.) Doesn't this make t-tests useless? Thank you in advance: P?ter Juh?sz