Hi Group, I'm looking for a method to calculate sample size for a non-inferiority survival analysis. Initially I've used cpower() of Hmisc, switching the roles of type-I and type-II errors, as cpower() assumes no treatment difference as the null hypothesis. Now, I would like to introduce event rate difference under the null-hypothesis, and calculate sample size accordingly. Any ideas? (similar functionality exists in nBinomial function of gsDesign for binomial tests) Thanks, Ehud