search for: gsdesign

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2017 Sep 24
2
gsDesign Pocock & OBF boundary
Sorry for messed up text. Here it goes again: I am learning to use the gsDesign package. I have a question about Pocock and OBF boundary. As far as I can understand, these 2 boundaries require equal spacing between interim analyses (maybe this is not correct?). But looks like I can still use gsDesign to run an analysis based on unequal spacing:? > gsDesign(k=2,test.type=2,t...
2017 Sep 22
2
gsDesign Pocock & OBF boundary
Hi, I am learning to use your gsDesign package!?I have a question about Pocock and OBF boundary. As far as Iunderstand, these 2 boundaries require equal spacing between interim analyses(maybe this is not correct?). But I can still use gsDesign to run an analysisbased on unequal spacing:?gsDesign(k=2,test.type=2,timing=c(0.75,1),alpha=0....
2017 Sep 24
0
gsDesign Pocock & OBF boundary
...cran.r-project.org/web/packages/reprex/index.html (read the vignette) -- Sent from my phone. Please excuse my brevity. On September 23, 2017 9:53:05 PM PDT, array chip via R-help <r-help at r-project.org> wrote: >Sorry for messed up text. Here it goes again: >I am learning to use the gsDesign package. >I have a question about Pocock and OBF boundary. As far as I can >understand, these 2 boundaries require equal spacing between interim >analyses (maybe this is not correct?). But looks like I can still use >gsDesign to run an analysis based on unequal spacing:? >> gsDesi...
2017 Sep 23
0
gsDesign Pocock & OBF boundary
> On 23 Sep 2017, at 01:32, array chip via R-help <r-help at r-project.org> wrote: > > Hi, > > I am learning to use your gsDesign package! I have a question about Pocock and OBF boundary. As far as Iunderstand, these 2 boundaries require equal spacing between interim analyses(maybe this is not correct?). But I can still use gsDesign to run an analysisbased on unequal spacing: gsDesign(k=2,test.type=2,timing=c(0.75,1),alpha=0....
2023 Nov 20
0
gsDesign 3.6.0 is released
Dear all, I'm excited to announce that a new version of gsDesign (3.6.0) is now on CRAN (https://cran.r-project.org/package=gsDesign). gsDesign supports group sequential clinical trial design, largely as presented in Jennison and Turnbull (2000). The 3.6.0 update introduces some significant new features and enhancements: - New gsSurvCalendar() function to enab...
2023 Nov 20
0
gsDesign 3.6.0 is released
Dear all, I'm excited to announce that a new version of gsDesign (3.6.0) is now on CRAN (https://cran.r-project.org/package=gsDesign). gsDesign supports group sequential clinical trial design, largely as presented in Jennison and Turnbull (2000). The 3.6.0 update introduces some significant new features and enhancements: - New gsSurvCalendar() function to enab...
2011 Nov 14
1
gsDesign
I'm trying to use gsDesign for a noninferiority trial with binary endpoint. Did anyone know how to specify the trial with different sample sizes for two treatment groups? Thanks in advance! [[alternative HTML version deleted]]
2009 Dec 17
2
SPLUS Seqtrial vs. R Packages for sequential clinical trials designs
...al.” So now I’m looking for alternative software. Two programs that seem promising are SPLUS Seqtrial and R.   I recently obtained a 30 day trial for the SPLUS Seqtrial add-on and have worked my way through most of the examples in the manual. I’ve also gotten access to R, installed a package called gsDesign, and worked through most of the examples in its documentation.   Although I don’t yet have a good understanding of the various approaches to sequential clinical trials designs, I thought that the gsDesign package seemed very impressive. I also understand that there are several other R packages tha...
2011 Aug 04
1
Multiple endpoint (possibly group sequential) sample size calculation
Hello everyone, I need to do a sample size calculation. The study two arms and two endpoints. The two arms are two different cancer drugs and the two endpoints reflect efficacy (based on progression free survival) and toxicity. Until now, I have been trying to understand this in terms of a one-arm design, where the acceptable rate of efficacy might be 0.40, the unacceptable rate of efficacy
2010 Jan 11
0
Non-inferiority log-rank test
...ching the roles of type-I and type-II errors, as cpower() assumes no treatment difference as the null hypothesis. Now, I would like to introduce event rate difference under the null-hypothesis, and calculate sample size accordingly. Any ideas? (similar functionality exists in nBinomial function of gsDesign for binomial tests) Thanks, Ehud
2012 Feb 20
1
Triangular Test
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2010 Mar 14
3
CRAN (and crantastic) updates this week
...(2.0), far (0.6-3), farmR (1.1), FD (1.0-7), flashClust (1.00), flexmix (2.2-5), fmri (1.4-0), forensim (1.1-4), FrF2 (1.1), ftsa (1.5), fxregime (1.0-0), GAMens (1.1.1), gcExplorer (0.9-3), GEOmap (1.5-4), GeoXp (1.4.2), GeoXp (1.4.3), ggplot2 (0.8.7), gmt (1.1-4), gRapHD (0.1.6), gRbase (1.3.4), gsDesign (2.2-11), gstat (0.9-69), gWidgetsRGtk2 (0.0-62), gWidgetstcltk (0.0-31), helloJavaWorld (0.0-7), hergm (1.1-1), HiddenMarkov (1.3-1), hyperdirichlet (1.4-2), ibr (1.2.1), ic.infer (1.1-3), Imap (1.32), integrativeME (1.2), integrOmics (2.55), interval (0.9-9.6), ipw (1.0-4), kml (1.1.1), ks (1.6.1...