Dear List,
I would like to know if there exist some R implementation of John
Whitehead's procedures for the planning and analysis of group sequential
clinical trials. His book is enlightenig but somewhat frustrating : it
has a good basic exposition of his framework, but the technical details
are sparse, and leave much work to do when one plans to reuimplement
part of the procedures. For example, one has to work out the computation
of test regions in non-trivial cases, the P-value and confidence
interval building, etc ... Given my abilities, I'd rather *not* do this ...
Did someone implement these procedures in R ? I am aware of a
(commercial) implementation in S+, but Googling for an R implementation
(and looking in the r-help archive) was ... well ... frustrating.
If no one did, and there is some interest, I might try to derive the
necessary steps and reimplement this.
Sincerely,
Emmanuel Charpentier
PS : please Cc: me your answers, since I'm not on the list and reading
it through the archives.
--
Emmanuel Charpentier Tel : +33-(0)1 40 27 35 98
Secr?tariat Scientifique du CEDIT Fax : +33-(0)1 40 27 55 65
Assistance Publique - H?pitaux de Paris
3, Avenue Victoria, F-75100 Paris RP - France
