I have successfully installed Reason 5 in Wine with Ubuntu 10.04. No matter what compatibility setting I choose, I can't click the "File-View-Edit etc.) buttons at the top. All other menus work, as well as key shortcuts, but that means I can't change any of my preferences in the program. Any help is greatly appreciated.
This is a known issue with Reason 5. As a work around you can use the keyboard to navigate the menus.