I can confirm this problem. The effect with Runes of Magic shows as follows: When running in windowed mode, or with"capture mouse in full-screen windows" option disabled, the cursor freezes after dragging the mouse with buttons pressed (eg when moving character). After a few second, behaviour returns to normal until you try again... When running in full-screen mode and with graphics option "capture mouse in full-screen windows" enabled, the mouse cursor freezes completely. However, the mouse still moves in the background and you can even select items by chance, it is just not visible any more as the cursor image remains frozen. This behaviour seems to be inherent to all Wine 1.3.X versions, issued so far. Cheers, Stefan