I have been experiencing the same problem ever since I upgraded to 1.3.9.
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The program uninstaller.exe has encountered a serious problem and needs to
close. We are sorry for the inconvenience.
This can be caused by a problem in the program of a deficiency in Wine. You may
want to check http://appdb.winehq.org for tips about running this application.
If this problem is not present under Windows and has not been reported yet, you
can report it at http://bugs.winehq.org.
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This happens every time I attempt to launch the Wine uninstaller. Like the OP I
am also running Ubuntu 10.10.
I am about to run off and file a bug but I wanted to post this here as well to
let everyone know that this is not a problem isolated to a single user. Until I
saw this post I was concerned that I was the only one experiencing the problem.