wine users - Nov 2010 - Run Multiple instances of a game through wine

I've managed to get two instances of Guild Wars to run at the same time
through wine.  How can I set wine or my computer up so that each instance takes
inputs from different keyboard/mouse sets?

My wife's computer broke but I had the idea to see if we could both just
play the game off of one machine.

That's called multiseat linux, and it hard to do at the moment.
See e.g.
http://www.phoronix.com/scan.php?page=news_item&px=NzQxMg