Hi R-help, I am trying to use 'samr' for 10 pre and post paired samples to test whether post is different from pre (i.e., the location shift for the delta of (post-pre)). However, I got an error message saying > samr.obj<-samr(d, resp.type="Two class paired", nperms=100, random.seed=100) perm= 1 Error in !logged2 : invalid argument type Does anyone know what this means? or how to solve this error? Also, the options 'One Sample paired' is for testing the differences directly (d1, d2,...), I suppose. The source code is ***************************************** function() { library(samr) attach(proto_data) x <- cbind(pre1, pre2, pre3, pre4, pre5, ... post1, post2,post3,post4,post5, ....) y <- c(-(1:10),1:10) d <- list(x=x,y=y, geneid=array.id) samr.obj<-samr(d, resp.type="Two class paired", nperms=100) samr.plot(samr.obj) } ***************************************** Thank you HS