Hi, I've been trying to use the impute2mach function in the GenABEL library. I unfortunately cannot make a working example as when I scale down the files I no longer get an error message. The error message that I get on the full file is: Error in checkSlotAssignment(object, name, value) : assignment of an object of class "NULL" is not valid for slot "data" in an object of class "databel"; is(value, "externalptr") is not TRUE The screen out put is: impute2mach(geno = "chr22_1000G.gen",info = "chr22_info", sample "1000G.sample",machbase = "chr22_test", maketext = F, order_info = c(2:7), skip_info = 0) Options in effect: --infile = chr22_1000G.gen --outfile = ./tmp841924 --skiprows = OFF --skipcols = 5 --cnrow = OFF --rncol = ON, using column 2 of 'chr22_1000G.gen' --transpose = ON --Rmatrix = OFF --nanString = NA Number of lines in source file is 120030 Number of words in source file is 11207 skiprows = 0 cnrow = 0 skipcols = 5 rncol = 2 Rmatrix = 0 numWords = 11207 Creating file with numRows = 120030 Creating file with numColumns = 11202 text2fvf finished. Data file size (13928) differs from the expected (1083336944) [120030,11202] Error in checkSlotAssignment(object, name, value) : assignment of an object of class "NULL" is not valid for slot "data" in an object of class "databel"; is(value, "externalptr") is not TRUE I was wondering if anyone else had got this error? Is it just the size of the file that creates the problem? Thanks, Natalie -- View this message in context: http://r.789695.n4.nabble.com/impute2mach-GenABEL-conversion-problem-tp2290062p2290062.html Sent from the R help mailing list archive at Nabble.com.