Hi there, I was trying to fit this dataset into LR model. This dataset includes 18 normal and 17 cancer. There are totally 14 markers (7 mRNAs and 7 Proteins). When I fitted into LR model, R gave me warning: Warning messages: 1: algorithm did not converge in: glm.fit(x = X, y = Y, weights = weights, start = start, etastart = etastart, 2: fitted probabilities numerically 0 or 1 occurred in: glm.fit(x = X, y = Y, weights = weights, start = start, etastart = etastart, I don't know why the algorithm did not converge. Is it because sample size/marker is small? Is it possible you run this dataset in s-plus? Thank you very much for your help. Michael ---------------------------------