Hi, I would like to use constrained splines in a GLM model (Poisson link) to take into account the nonlinear effect of some covariate. The constraints I need are described below. I have several variables that I need concurrently in the same model. I looked at package mgcv but I do not know if/how I can use it in GLM (not GAM) : I could not manage to adapt the mono.con(mgcv) example to GLM. The help for package fda is not complete. Not sure that backSpline(splines) does what I need. isoreg (modreg) seems to do univariate regressions. Some of my covariates are linear. Three covariates (x1,x2 and x3) must be transformed in a decreasing and convex way like this: |o |o | o | o | o | o | ooooo |----------------- Currently, I use exp(-x1/alpha1)+exp(-x2/alpha2)+exp(-x3/alpha3), I try several alpha's and choose the best according to log-likelihood. One variable should have only one local maximum (that is, the derivative should be zero only once, which is at the top), like this: | | TOP | oo | o o | o o |o o o | o o |-------------------- with bs() or ns() and no constraint, I get: | | TOP | oo |o o o | o o o | o | o o |-------------------- which is nonsense (note there are very few observations on the left part) I also tried some parametric forms, choosing via log-likelihood. But with four covariates, it is a lot of parameters to try (several hours with little flexible functions). I am looking for something similar to ns or bs (package splines), which are very convenient to place in the formula of a GLM model. I tried them, adjusting knots, but could not manage what I want. Constraints on some derivatives may do the trick, but I do not know how to implement them in R. Any help or comment would be greatly appreciated ! Mayeul KAUFFMANN Universit?? Pierre Mend??s France - Grenoble France