Dear listers, I would like to get the bootstrap estimates form my lme model. I have an HLM (multillevel) 2-level model with the dichotomous outcome. I used glmmPQL procedure. However I have a problem since I have a rather unbalanced proportion (90-99% of events, i.e. ones and only 1-10% of nonevents - zeros) although sample sizes are not that small between 500 and 1000 I get pretty weird and large SE. Nothing really surprising considering the facts - therefore one of the solutions would be to get the bootstrap estimates of the SE. How could that be acheived? I checked the boot command in the package "boot", however I'm not really sure how to tell the him that I'm running a glmmPQL model? Has anyone some experience with that? I also have one concern... since the SE in the lme models are not just ordinary SE... is there any reservation in using a regular bootstrap on them? Are there any special bootstrap tools for that? thanks for all the help best Andrej _________ Andrej Kveder, M.A. researcher Institute of Medical Sciences SRS SASA; Novi trg 2, SI-1000 Ljubljana, Slovenia phone: +386 1 47 06 440 fax: +386 1 42 61 493 [[alternative HTML version deleted]]