Hi, I am constructing a series of nonlinear mixed regression models at multiple spatial scales on the same data. The data is a regular grid of cells. A coarser scale is achieved, for example, by aggregating cells in blocks that are 2x2 cells in dimension and averaging dependent and independent data over this block. Some 2x2 blocks will be missing data for several expected reasons and these blocks are of interest and so cannot be easily discarded (they are also likely not at random). I would like to take this into account when fitting the model. A simple weighting of each block by number of complete component observations (e.g. no missing data would have a weight of 2x2=4) seems intuitive. I've reviewed the NLME documentation and weighting schemes seem to be the usual variety of accounting for unequal variance. Is there a work around to specify the integer weights I described above? I've toyed with a work around where I duplicate each block observation by the number of observations summarized within it. Of course, this is difficult to do correctly as the sample size will be inflated and most statistics not easily interpretable. Any advice on how to proceed is welcome. Thanks. -seth -- View this message in context: http://n4.nabble.com/weight-by-obs-in-spatial-nest-in-NLME-tp1009168p1009168.html Sent from the R help mailing list archive at Nabble.com.