jeka12386
2012-Jun-05 22:55 UTC
[R] How to compute boundaries for bivariate normal distribution in group sequential design
Hi all Dear all, I need to compute boundaries for 3 stages group sequential design with 2 variables using Simpson?s integration method. There is a r program written by Michael A. Proschant et Al. (2006) (Statistical Monitoring of Clinical Trials: A Unified Approach) ? see file attached ? to calculate boundaries for 1 variable only. Does anyone know how this program can be modified to incorporate a second variable? Or propose an alternative solution please? Many thanks Jeka http://r.789695.n4.nabble.com/file/n4632450/Boundary.R Boundary.R -- View this message in context: http://r.789695.n4.nabble.com/How-to-compute-boundaries-for-bivariate-normal-distribution-in-group-sequential-design-tp4632450.html Sent from the R help mailing list archive at Nabble.com.