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proschan
2012 Jun 05
0
How to compute boundaries for bivariate normal distribution in group sequential design
Hi all
Dear all,
I need to compute boundaries for 3 stages group sequential design with 2
variables using Simpson?s integration method.
There is a r program written by Michael A. Proschant et Al. (2006)
(Statistical Monitoring of Clinical Trials: A Unified Approach) ? see file
attached ? to calculate boundaries for 1 variable only.
Does anyone know how this program can be modified to incorporate a second
variable? Or propose an alternative solution please?
Many thanks
Jeka
http:...