I've found most games in OSX that has to use Xquartz X11 does NOT run right
at all without using a virtual desktop. This is due to limitations in Xquartz
itself.... its decent and getting better, but for Wine gaming, Xquartz really
stinks.
You might look into making wrappers (or finding some others have made) using
Wineskin (http://wineskin.sourceforge.net). I have some work arounds its does
for fullscreen gaming... including changing resolutions and such.... that
Xquartz cannot even do. Its not perfect, but better than trying just using
standard X11.app Xquartz.... plus you end up with just a normal double click to
run .app, so it seems very Mac native.