I've tried Alcohol120, Clone Drive, CD Rom Emulator and daemontools but none of them work for me with Wine. Anybody knows that virtual CD program works in Wine?
You need to use native linux tools. Simple iso files can be mounted 'mount -t iso9660 -o loop filename.iso /mnt/iso' but in various cases you need a real '/dev/cdrom' file when a game wants to read disc sectors or the title. For such cases use 'cdemu' available at http://www.cdemu.org.