R sig jobs - Oct 2014 - JOBS: New positions in computational biology, bioinformatics, statistics, HPC and software engineering

Dear all,
The CRUK MI have multiple positions in and around bioinformatics, biostatistics
and computational biology.

These range from HPC and mathematical programming, through biostatistics and
biomarkers, to computational biology and bioinformatics. Focuses include single
cell genomics and personalised medicine in lung and prostate cancer.

For full details, please visit our website at:

http://www.cruk.manchester.ac.uk

Brief summaries below:

RNA Biology Group - Crispin Miller
=========================Postdoctoral Scientist in Computational Biology:
A position is now available for a highly motivated postdoctoral research
scientist to develop computational models of gene expression across populations
of cells, and to ask how they change in tumours. The goal is to identify novel
regulatory noncoding RNA molecules that are disrupted in cancer.

4 Year PhD Studentship:
This project will involve applying machine learning and pattern recognition
techniques to high volumes of RNA-sequencing data representing a combination of
single cells and bulk tissue. The scale of the data mean that novel algorithms
will be required in order to achieve the volume of computation required, and
this will involve programming on the latest architectures. The successful
applicant will make extensive use of our on-site High Performance Computing
(HPC) facility, purpose built for the analysis of cancer genomics data.

Computational Biology Team leader:
Seeking a senior computational biologist who can provide leadership to the
Computational Biology Support team at the CRUK MI. They will work closely with
the RNA Biology Group leader to coordinate the activities of a team providing
state of the art analysis of high throughput genomics data.

Clinical and Experimental Pharmacology Group (CEP) - Caroline Dive
====================================================Bioinformatician:
We are now able to isolate single Circulating Tumour Cells (CTCs) from patients?
blood samples and derive their genomic profiles utilising next generation
sequencing (Hodgkinson et al Nature Medicine, June 2014). We will for the first
time using advanced molecular analysis define CTC heterogeneity and examine
differences in CTC genomic profiles of small cell lung cancer (SCLC) patients
who are sensitive or resistant to chemotherapy, an approach that will ultimately
lead to biomarker signatures for therapy selection.

2 x Postdoctoral Scientists (Biomarker Statisticians):
The successful candidates will be involved in biomarker driven clinical trial
design, the development of statistical methods tailored to biomarker analysis
(baseline and longitudinal data) and the analysis of resultant biomarker data
with a view to optimising patient treatment.

Molecular Oncology Group - Richard Marais & CEP Group - Caroline Dive
=======================================================Post-doctoral Scientist
in Bioinformatics for Prostate Cancer - Prostate Cancer UK/Movember Funded:
Together with Queen?s University Belfast, we have recently been awarded a
Movember Centre of Excellence for prostate cancer research.The successful
candidate will join a team who will implement personalised medicine for prostate
cancer.  The post holder will be responsible for working with other team members
to integrate genomics and proteomics data from patient samples.  They will
collaborate to advance the data for practical use in the personalised medicine
platform and to pursue follow-up studies as appropriate.

Stem Cell Biology Group - Georges Lacaud
================================Bioinformatics analyst:
seeking a proactive and well-organised candidate with excellent communication
and interpersonal skills to work in a dynamic laboratory undertaking cutting
edge research. The successful candidate will be expected to provide expert
analysis of Microarray data, Next Generation and ChIP Sequencing using a range
of bioinformatics methods and resources.

About the Institute: The Cancer Research UK Manchester Institute
(www.cruk.manchester.ac.uk<http://www.cruk.manchester.ac.uk>), an
Institute of The University of Manchester
(www.manchester.ac.uk<http://www.manchester.ac.uk>), is a world-leading
centre for excellence in cancer research. The Institute is core funded by Cancer
Research UK (www.cancerresearchuk.org<http://www.cancerresearchuk.org>),
the largest independent cancer research organisation in the world. We are
adjacent to The Christie NHS Foundation Trust
(www.christie.nhs.uk<http://www.christie.nhs.uk>), one of the largest
cancer treatment centres in Europe. These factors combine to provide an
exceptional environment in which to pursue basic, translational and clinical
research programmes. Our aim is to understand the fundamental basis of cancer
and apply that knowledge to developing new treatment strategies for cancer
patients. Our advanced research programmes span a spectrum of cancer research,
from the molecular and cellular basis of cancer through to drug discovery,
translational research and clinical trials. The Institute has outstanding
laboratory facilities and exceptional core services, including next generation
sequencing, microarrays, confocal microscopy, bioinformatics, histology and
mass-spectrometry. We are situated in Manchester, England, a vibrant and dynamic
city that is surrounded by beautiful countryside and has excellent transport
links both nationally and internationally.
________________________________

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