Hi, I have two groups of persons, GRP0 and GRP1, on which I measured three continuous variables: VAR1, VAR2 and VAR3. I would like to use Mancova in R with: - VAR1, VAR2 and VAR3 as outcome variables - GRP={0,1} as predictor variable - age and gender = {F,M} as covariates What would be the correct way to formulate this model in R? Also, since the VAR1, VAR2 and VAR3 measures were carried out on the same persons at N=100 instances which were serially correlated, I would like to apply permutation-based multiple-comparison correction on the N=100 MANCOVA results I would obtain. Any help on this matter as well would be fantastic. Best wishes, Michael [[alternative HTML version deleted]]