Dear R-Community, I'm trying to estimate the parameters of a probability distribution function by maximum likelihood estimation (using the stats4 function mle()) but can't seem to get it working. For each unit of observation I have a pair of observations (a, r) which I assume (both) to be log-normal distributed (iid). Taking the log of both values I have (iid) normally distributed random variables and the likelihood function to be estimated is: L = Product(F(x_i) - F(y_i), i=1..n) where F is the Normal PDF and (x,y) := (log(a), log(r)). Taking the log and multiplying by -1 gives the negative loglikelihood l = Sum(log( F(x_i) - F(y_i) ), i=1..n) However estimation by mle() produces the error "vmmin is not finite" and "NaN have been created" - even though put bound on the parameters mu and sigma (see code below). library("stats4") gaps <- matrix(nrow=10, ncol=4, dimnames=list(c(1:10),c("r_i", "a_i", "log(r_i)", "log(a_i)"))) gaps[,1] <- c(2.6, 1.4, 2.2, 2.9, 2.9, 1.7, 1.3, 1.7, 3.8, 4.5) gaps[,2] <- c(9.8, 20.5, 8.7, 7.2, 10.3, 11, 4.5, 5.2, 6.7, 7.6) gaps[,3] <- log(gaps[,1]) gaps[,4] <- log(gaps[,2]) nll <- function(mu, sigma) { if(sigma >= 0 && mu >= 0) { -sum(log(pnorm(gaps[,3], mean=mu, sd=sigma) - pnorm(gaps[,4], mean=mu, sd=sigma))) } else { NA } } fit <- mle(nll, start=list(mu=0, sigma=1), nobs=10) print(fit) To be honest, I'm stumped and don't quite know what the problem is... Regards and Thanks, Ronald Kölpin