I am currently working a meta-analysis that is exploring the effect of a drug on plasma lipid levels. However, I am primarily interested in assessing the overall dose-response relationship with mean change in lipids. I have used the metafor package to conduct a meta-regression but is there a way to determine if this relationship is linear? Something like a p-value for trend? Thanks so much! ________________________________ PHRI DISCLAIMER This information is directed in confidence solely to the person named above and may not otherwise be distributed, copied or disclosed. Therefore, this information should be considered strictly confidential. If you have received this email in error, please notify the sender immediately via a return email for further direction. Thank you for your assistance. [[alternative HTML version deleted]]
Viechtbauer Wolfgang (STAT)
2013-Sep-19 19:11 UTC
[R] Dose-response relationship using metafor?
Can you provide a minimal and self-contained example showing/illustrating what you have done and would like to test? Based on the information provided, I could only make a vague suggestion along the lines of: You could include dose in an appropriate meta-regression model and then examine whether polynomial versions of the dose variable are significant (which would suggest a non-linear relationship). Best, Wolfgang -- Wolfgang Viechtbauer, Ph.D., Statistician Department of Psychiatry and Psychology School for Mental Health and Neuroscience Faculty of Health, Medicine, and Life Sciences Maastricht University, P.O. Box 616 (VIJV1) 6200 MD Maastricht, The Netherlands +31 (43) 388-4170 | http://www.wvbauer.com> -----Original Message----- > From: r-help-bounces at r-project.org [mailto:r-help-bounces at r-project.org] > On Behalf Of Ross, Stephanie > Sent: Wednesday, September 18, 2013 21:41 > To: r-help at r-project.org > Subject: [R] Dose-response relationship using metafor? > > I am currently working a meta-analysis that is exploring the effect of a > drug on plasma lipid levels. However, I am primarily interested in > assessing the overall dose-response relationship with mean change in > lipids. I have used the metafor package to conduct a meta-regression but > is there a way to determine if this relationship is linear? Something like > a p-value for trend? > Thanks so much! > > ________________________________ > PHRI DISCLAIMER This information is directed in confidence solely to the > person named above and may not otherwise be distributed, copied or > disclosed. Therefore, this information should be considered strictly > confidential. If you have received this email in error, please notify the > sender immediately via a return email for further direction. Thank you for > your assistance. > > [[alternative HTML version deleted]] > > ______________________________________________ > R-help at r-project.org mailing list > https://stat.ethz.ch/mailman/listinfo/r-help > PLEASE do read the posting guide http://www.R-project.org/posting- > guide.html > and provide commented, minimal, self-contained, reproducible code.