Dear useRs, I have a univariate spline application where I have a fixed set of independent variable values. I would like to be able to generate an interpolating spline, given a set of dependent variables, which can easily return the value of the interpolant over its entire range, for use in an intensive variational problem. I am familiar with stats:spline, stats:splinefun and splines::interpSpline. The reason I cannot simply use those functions is that there are caveats on the interpolant. I would like the degree of the interpolant to vary from cubic over part of the range, while still keeping the maximum orders of derivative continuities possible at the changepoints. In other words, over some parts of the domain the interpolant will be piecewise cubic, while over other parts it might be piecewise linear and/or quadratic. I can kludge some splines::bs() calls and their subsequent predict() calls together, by going under their hoods and manipulating their parts and attributes, then using these as the right hand side of an lm() call. There are a couple of issues with this. First, while I may get this kludge to work at first, under the hood these objects are no longer correctly specified for being proper "bs" objects. The next application of these functions might fail badly. Second, I do not have a handle on the scope of the variational problem, and thus do not know of a permanent fine grid to use. Therefore this method requires reevaluating the bs() and predict() call for different grids, and thus performing the subsequent kludges numerous times. So may I be privy to efficient ways, if any, to customize an interpolating spline in this way in R? My ideal solution would easily produce a function analogous to the output of stats::splinefun, but which account for the varied orders. Websearching was not helpful. Thanks, John John Szumiloski, Ph.D. Associate Principle Scientist, Biostatistics Biometrics Research WP53B-120 Merck Research Laboratories P.O. Box 0004 West Point, PA 19486-0004 (215) 652-7346 (PH) (215) 993-1835 (FAX) Notice: This e-mail message, together with any attachme...{{dropped:14}}