I suspect you received no reply as no one knows what you mean by
"global fit analysis." If you have some specific technical definition
in mind, provide a reference. Better yet, SEARCH (see CRAN's Task
Views).
If you are merely mis-referring to "goodness of fit" measures, than
all R's modeling functions in all packages provide such measures, this
is a statistics-- not an R -- question, and you need to do some
reading or consult a local statistician, not pester this list further.
Cheers,
Bert
On Tue, Jul 9, 2013 at 11:17 AM, Asan Ramzan <asanramzan at yahoo.com>
wrote:> I sending this again as I forgot to add a subject
>
>
> Hello R-help
>
> Does anyone know if there is a package for global
> fit analysis and if so how to use it. I am trying to calculate the Kd
> value of a protein interacting with its ligand (When protein interacts
> with ligand this effect a number of residues). The table below
> shows with increasing concentration of ligand changes in three different
> residues.
>
> Concentration res1 res2 res3
> 0 0 0 0
> 1.99167E-05 0.012978 0.020862 0.03032
> 3.95847E-05 0.019562 0.032288 0.048266
> 7.82652E-05 0.021842 0.036 0.05521
> 0.000115656 0.025274 0.043862 0.06398
> 0.000151801 0.029896 0.048762 0.075302
> 0.000186741 0.033544 0.053556 0.084334
> 0.000220516 0.035676 0.058964 0.0914
> 0.000274932 0.037834 0.061818 0.097096
> 0.000352021 0.040694 0.066216 0.100024
> 0.000422686 0.04329 0.070414 0.109974
> 0.000552238 0.045482 0.074646 0.116072
> 0.000777155 0.047062 0.07671 0.118722
> 0.0012 0.05345 0.08602 0.130344
> [[alternative HTML version deleted]]
>
>
> ______________________________________________
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> PLEASE do read the posting guide
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> and provide commented, minimal, self-contained, reproducible code.
>
--
Bert Gunter
Genentech Nonclinical Biostatistics
Internal Contact Info:
Phone: 467-7374
Website:
http://pharmadevelopment.roche.com/index/pdb/pdb-functional-groups/pdb-biostatistics/pdb-ncb-home.htm