Hi, I am looking for the best way or best package available for simulating a genetic association between a specific SNP and a quantitative phenotype. All of the packages I saw in R seem to be specialised in pedigree data or in population data where coalescence and other evolutionary factors are specified, but I don't have any experience in population genetics and I only want to simulate the simple case of European population which is the most similar to my real data, having a normal distribution for the trait and an additive effect for the genotype. I am looking for something in R similar to the function in Plink where one needs to specify a range of allele frequencies, a range for the phenotype, and a variant which should result associated with the genotype. Can someone please help me? Thank you very much. James [[alternative HTML version deleted]]