Dear all, I am calculating each-against-each correlations for a number of variables, in order to use the correlations as distances. This is easy enough using just cor(), but not if I want to have a p-value for each calculated correlation, and especially if I want to correct them for multiple testing (but see below). I do that currently "on foot", looping around the variables to apply cor.test to each combination of two variables. Is there a function or a package that would do that for me? Specifically, what I do is # a is the data matrix for( i in 1:ncol( a ) ) { for( j in (i+1):ncol(a) ) { result <- cor.test( a[,i], a[,j], method="spear" ) # store the result somehow } } This is slow and I seek a better solution. As I mentioned before, I correct the p-values using Bonferroni correction, which does not assume independence of the hypotheses to be tested (obviously that is the case here). However, is there a better method to do this? Bonferroni results in a large number of false negatives. Kind regards, j. -- -------- Dr. January Weiner 3 --------------------------------------