Hi there, I had a problem when I hoped to get confidence intervals for the parameters I got using mle() of stats4 package. This problem would not appear if ``fixed'' option was not used. The following mini-example will demo the problem: x <- c(100, 56, 32, 18, 10, 1) r <- c(18, 17, 10, 6, 4, 3) n <- c(18, 22, 17, 21, 23, 20) loglik.1 <- function(alpha, beta, c) { x <- log10(x) P <- c + (1-c) * pnorm(alpha + beta * x) control <- which(x == -Inf) if (length(control) != 0) P[control] <- c P <- pmax(pmin(P,1),0) -(sum(r * log(P)) + sum((n - r)* log(1-P))) } loglik.2 <- function(alpha, beta) { x <- log10(x) P <- pnorm(alpha + beta * x) P <- pmax(pmin(P,1),0) -(sum(r * log(P)) + sum((n - r)* log(1-P))) } library(stats4) fit.1 <- mle(loglik.1, start = list(alpha = 0, beta = 0, c = 0), method = "BFGS", fixed = list(c=0)) fit.2 <- mle(loglik.2, start = list(alpha = 0, beta = 0), method = "BFGS", fixed = list()) > confint(fit.1) Profiling... Error in approx(sp$y, sp$x, xout = cutoff) : need at least two non-NA values to interpolate In addition: Warning message: In approx(sp$y, sp$x, xout = cutoff) : collapsing to unique 'x' values > confint(fit.2) Profiling... 2.5 % 97.5 % alpha -2.5187909 -1.144600 beta 0.9052395 1.876322 The version I test the above code is 2.11.1 and 2.13.1. I hope to know what's the matter? and how to avoid the error, and get the correct confidence intervals for the parameters? Any suggestions will be really appreciated. P.S.: I noticed that there was a file named mle.R.rej in the source directory of stats4. A broken patch? Thanks! Regards, Jinsong