Hi, I am new to R statistics.I am doing microarray analysis. For which I have text file "__.txt[1]" which contains 47 columns and 43377 rows including the first row and first column with headers(names). I need to write a code to normalize using cyclic loess. I see this formula for it: normalize.loess(mat, subset = sample(1:(dim(mat)[1]), min(c(5000, nrow(mat)))), epsilon = 10^-2, maxit = 1, log.it = TRUE, verbose = TRUE, span = 2/3, family.loess = "symmetric") one of the paper said normalize.loess(data,epsilon=1,log.it=F,span=0.4,maxit=2). The data for epsilon,log.it,span and maxit have to be as mentioned in the paper.I am not aware as to what matrix parameters do I have to give. Any help on this will be appreciated. Thank u in advance -- View this message in context: http://r.789695.n4.nabble.com/Cyclic-loess-tp3007856p3007856.html Sent from the R help mailing list archive at Nabble.com.