Dear All, I am new to this list, and also to population modeling with R (nlmeODE). Could someone send me a simple example how to do posthoc-type estimate (for example, for the Theoph.nlme model in PKPDmodels library): I have a PK model, and I have a new subject. How to estimate individual parameters for a new subject based on the population model? In general, what would be the best book/tutorial/online resource to learn nlmeODE package (I am a nonmem user, so just need to see examples or clear description of how it needs to be done); I do not want to bother r-help too often but the R-help included into the package is not very detailed. Thanks! Leonid -- -------------------------------------- Leonid Gibiansky, Ph.D. President, QuantPharm LLC web: www.quantpharm.com e-mail: LGibiansky at quantpharm.com tel: (301) 767 5566