Hi In my experiment I have 2 Groups (control patient) and 4 blocks of trials per subject, n=12 for Control and n=11 for patient The variances of the patients is very much higher than that of the Control. 1- I tried an ANOVA with Groups as between factor and Blocks as within factor (repeated measures). aov(Y ~ gr*block+Error(subj/block), data=d) works OK but without the significant effect I was looking for, which may be caused by the variances. So I though I¹d use lme.... 2- lme.m = lme(Y ~ gr*block, data=d, random=~1 + block | subj); anova(lme.m) I¹d like to make sure that my lme model is correctly psecified. Thanks in advance for your help! __________________ Patrick Bédard Ph.D. Dept. of Neuroscience Brown University [[alternative HTML version deleted]]