Hello everybody Someone know how I can determine the global maximum from a sm.spline second derivative and a 95% confidence limits for that point? Thanks in advance -- Lic. Nahuel E. Farias Laboratorio de Invertebrados Departamento de Biolog?a Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar Del Plata, CC 1245, CP 7600 Mar del Plata, Argentina Tel. + 54 - 0223 - 4752426 (Int. 466)