Hi, I need to use the Smoothing Spline Clustering (SSC): genemerge.bioteam.net/SSClust-Manual.pdf But it doesn't work! If someone can try it and help me! In the folder you will find a file named SSClust.R, but, I do not why, it doesn't work. Also the SSClust.test.R file doesn't work, but it produced a part of the total output (you can see in the Example folder the real "predicted" output). I guess that the "error" is at line 178 [>temp.pred=predict(temp,data.frame(my.time=tt.grid),se.fit=T)] I'm writing my PhD thesis and I'm in hurry...please help me!! Marco ps: if instead of ssanova (at line 176), you use lm everything go well