Dear all, how can I perform a repeated measures ANOVA using a covariance matrix as input? E.g., I have four repeated measures (N = 200) with mean vector tau (no BS factor): tau <- rbind(1.10, 2.51, 2.76, 3.52) and covariance matrix (sigma): sigma <- matrix(c(0.523, 0.268, 0.267, 0.211, 0.268, 0.444, 0.492, 0.571, 0.267, 0.492, 1.213, 1.112, 0.211, 0.571, 1.112, 1.811), nrow = 4, ncol = 4, byrow = TRUE) Thank you very much in advance!