Hi R-masters! I trying model Heart disease mortality in my country with a lme model like this: m1.lme<-lme(log(rdeath)~age*year,random=~age|year,data=dados) where: rdeath is rate of mortality per 100000 person per age and year age: age of death (22 27 32 37 42 47 52 57 62 67 72 77 82) year: year of death (1980:2002) I don?t have problem to fit the model, but in residual analysis I have one problem. If i type acf(m1.lme$residuals) the graph show 4 plot with a sin curve (a example in attach) and I get this variogram: > Variogram(m1.lme) variog dist n.pairs 1 0.3939065 1 276 2 0.6486452 2 253 3 0.9679870 3 230 4 1.2765094 4 207 5 1.4158147 5 184 6 1.4264685 6 161 7 1.4048608 7 138 8 1.1902613 8 115 9 0.9619330 9 92 10 0.7037427 10 69 11 0.8591257 11 46 12 1.2215657 12 23 Well I need help for solution this problem.... Somebody can help me? Thanks in advance Bernardo Rangel Tura, MD, MSc National Institute of Cardiology Laranjeiras Rio de Janeiro Brazil -------------- next part -------------- No virus found in this outgoing message. Checked by AVG Anti-Virus.