I'm running SAM in R package, I am analysing two affy array's groups data (two conditions in 3 separate pairs). I am using SAM starting from a filtered list containing 3000 genes but I had some problems. Infact when I analyze the delta table I have the number of the false positives that drastically goes down.For example, I have: Delta p0 False Called FDR 1 0.1 0.169 242.10 1259 0.033 2 0.2 0.169 31.10 272 0.019 3 0.4 0.169 2.50 23 0.018 4 0.5 0.169 1.10 13 0.014 5 0.7 0.169 0.15 3 0.008 6 0.8 0.169 0.15 3 0.008 7 1.0 0.169 0.10 2 0.008 8 1.1 0.169 0.05 1 0.008 9 1.3 0.169 0.05 1 0.008 10 1.4 0.169 0.05 1 0.008 anyone else has run across this and can tell me what should be done to solve it? Thanks mirella