Jean-Louis Abitbol
2008-Sep-29 13:55 UTC
[R] Script for dose proportionality assessment using power model and confidence interval criteria
Dear R-Helpers Has anyone written a script for the dose proportionality assessement using the power model and the confidence interval criteria as described in - Gough at al. Assessment of dose proportionality: report from the statisticians in the pharmaceutical industry in Drug Information Journal,1995, 29:1039-1048 and/or - Smith et al. Confidence interval criteria for assessment of dose proportionality in Pharmaceutical Research, 2000, 20:1278-1283 As an aside, and before tweaking the source of function NCAanalyze in the bear package, I wonder if anyone has a function for doing non compartimental PK analysis by subject on a dataframe with subject, time and concentration variates. Thanks in advance for sharing and helping me not re-invent the wheel (which might be square given my R skills). Best wishes, Jean-Louis Jean-Louis Abitbol, MD Chief Medical Officer Trophos SA, Parc scientifique de Luminy, Case 931 Luminy Biotech Entreprises 13288 Marseille Cedex 9 France Email: jlabitbol at trophos.com ---- Backup Email: abitbol at sent.com Cellular: (33) (0)6 24 47 59 34 Direct Line: (33) (0)4 91 82 82 73-Switchboard: (33) (0)4 91 82 82 82 Fax: (33) (0)4 91 82 82 89