xiao-jun ma
2007-Jun-10 20:20 UTC
[R] Question on weighted Kaplan-Meier analysis of case-cohort design
I have a study best described as a retrospective case-cohort design: the cases were all the events in a given time span surveyed, and the controls (event-free during the follow-up period) were selected in 2:1 ratio (2 controls per case). The sampling frequency for the controls was about 0.27, so I used a weight vector consisting of 1 for cases and 1/0.27 for controls for coxph to adjust for sampling bias. Using the same weights in Kaplan-Meier analysis (survfit) gave very inaccurate survival curves (much lower event rate than expected from population). Are weighting handled differently between coxph and survfit? How should I conduct a weighted Kaplan-Meier analysis (given that survfit doesn't accept a weighted cox model) for such a design? Any explanations or suggestions are highly appreciated, xiaojun