WinXP, Splus7 and R2.3.1. All, I have been using the SSfpl and SSlogis self-starting functions in the nlme library to fit 4PL and restricted 4PL models. I need to adapt these routines to fit the alternative model f(x) = A + (B-A)/(1 + abs(x/EC50)^C) My Question: How do I obtain good starting values for this alternative model? (The pseudo-code found on pages 517 - 520 of "Mixed Effects Models in S and Splus" is not applicable to my problem because it deals with f(x)=A+(B-A)/(1+exp(EC50-x)/C)) which is not the same function.) Many thanks, Greg