Hello sir: As to the 2*2 table format for reporting results comparing a new test to true diagnosis,when I got the sensitivity and specificity,how can I calculate the exact 95% confidence intervals (based on the binomial distribution) for sensitivity and specificity via R? Thanks a lot! My best! ------------------------------ ******************************************* Xin Meng Capitalbio Corporation National Engineering Research Center for Beijing Biochip Technology BioPharma-informatics & Software Dept. Research Engineer Tel: +86-10-80715888/80726868-6438 Fax: +86-10-80726790 Email??xmeng at capitalbio.com Address:18 Life Science Parkway, Changping District, Beijing 102206, China
"XinMeng" <xmeng at capitalbio.com> writes:> Hello sir:> As to the 2*2 table format for reporting results comparing a new > test to true diagnosis,when I got the sensitivity and > specificity,how can I calculate the exact 95% confidence intervals > (based on the binomial distribution) for sensitivity and specificity > via R?Just run binom.test on the data from each column (or row, depending on which way you turn the tables). -- O__ ---- Peter Dalgaard ?ster Farimagsgade 5, Entr.B c/ /'_ --- Dept. of Biostatistics PO Box 2099, 1014 Cph. K (*) \(*) -- University of Copenhagen Denmark Ph: (+45) 35327918 ~~~~~~~~~~ - (p.dalgaard at biostat.ku.dk) FAX: (+45) 35327907
Peter Dalgaard wrote:> "XinMeng" <xmeng at capitalbio.com> writes: > >> Hello sir: > >> As to the 2*2 table format for reporting results comparing a new >> test to true diagnosis,when I got the sensitivity and >> specificity,how can I calculate the exact 95% confidence intervals >> (based on the binomial distribution) for sensitivity and specificity >> via R? > > Just run binom.test on the data from each column (or row, depending on > which way you turn the tables). >But beware of exact binomial intervals - they are often not very accurate. Wilson and other intervals are generally better. For example see the binconf function in the Hmisc package. -- Frank E Harrell Jr Professor and Chair School of Medicine Department of Biostatistics Vanderbilt University
check package "binom".
I hope it helps.
Best,
Dimitris
----
Dimitris Rizopoulos
Ph.D. Student
Biostatistical Centre
School of Public Health
Catholic University of Leuven
Address: Kapucijnenvoer 35, Leuven, Belgium
Tel: +32/(0)16/336899
Fax: +32/(0)16/337015
Web: http://med.kuleuven.be/biostat/
http://www.student.kuleuven.be/~m0390867/dimitris.htm
----- Original Message -----
From: "XinMeng" <xmeng at capitalbio.com>
To: <r-help at stat.math.ethz.ch>
Sent: Wednesday, September 27, 2006 10:12 AM
Subject: [R] exact 95% confidence intervals
> Hello sir:
> As to the 2*2 table format for reporting results comparing a new
> test to true diagnosis,when I got the sensitivity and
> specificity,how can I calculate the exact 95% confidence intervals
> (based on the binomial distribution) for sensitivity and specificity
> via R?
>
> Thanks a lot!
>
> My best!
>
>
>
> ------------------------------
> *******************************************
> Xin Meng
> Capitalbio Corporation
> National Engineering Research Center
> for Beijing Biochip Technology
> BioPharma-informatics & Software Dept.
> Research Engineer
> Tel: +86-10-80715888/80726868-6438
> Fax: +86-10-80726790
> Email??xmeng at capitalbio.com
> Address:18 Life Science Parkway,
> Changping District, Beijing 102206, China
>
>
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