R help - Mar 2006 - a question related to clustering

Hello all,

 

I have a fundamental question to ask related to clustering.  As you
know, when we do statistic analysis, such as t-test, or anova, we like
to log transform our data to make it normally distributed.  My question
is shall we use signal intensity of affy chips to cluster or use log
transformed data.  The Dendrogram profiles are certainly different when
comparing two type of the data.

 

Thanks,

 

AG


	[[alternative HTML version deleted]]

Sounds like you should go to the Bioconductor website
http://www.bioconductor.org/ and get plugged into their extensive and
professionally written software instead of shaking and baking your own.

-- Bert Gunter
Genentech Non-Clinical Statistics
South San Francisco, CA
 
"The business of the statistician is to catalyze the scientific learning
process."  - George E. P. Box
 
 
> -----Original Message-----
> From: r-help-bounces at stat.math.ethz.ch 
> [mailto:r-help-bounces at stat.math.ethz.ch] On Behalf Of Li, 
> Aiguo (NIH/NCI) [C]
> Sent: Wednesday, March 22, 2006 2:16 PM
> To: r-help at stat.math.ethz.ch
> Subject: [R] a question related to clustering
> 
> Hello all,
> 
>  
> 
> I have a fundamental question to ask related to clustering.  As you
> know, when we do statistic analysis, such as t-test, or anova, we like
> to log transform our data to make it normally distributed.  
> My question
> is shall we use signal intensity of affy chips to cluster or use log
> transformed data.  The Dendrogram profiles are certainly 
> different when
> comparing two type of the data.
> 
>  
> 
> Thanks,
> 
>  
> 
> AG
> 
> 
> 	[[alternative HTML version deleted]]
> 
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