search for: preclinical

The right candidate will work closely with neuroscientists seeking to discover new medicines to treat Alzheimer?s disease, bipolar illness, schizophrenia and autism. He/she will be involved in the design and analysis of preclinical experiments covering all aspects of drug discovery from disease target identification through animal model development and demonstration of proof of concept. The responsibilities of this position can evolve over time to include support for early clinical trials work in these disease areas as well....

What is the correct form to write statement meaning: if (a==1) {b=2; c=3}; else {b=0; c=0}; Thank you Jue Wang, Biostatistician Contracted Position for Preclinical & Research Biostatistics PrO Unlimited (908) 231-3022

...rect function to extract the estimates of difference median of y-x) and the confidence interval of this estimates. Shall I go back to the package ExactRankTest? I do know how to extracted these values from function wilcox.exact there. Thank you Jue Wang, Biostatistician Contracted Position for Preclinical & Research Biostatistics PrO Unlimited (908) 231-3022

...t(y~x) Exact Wilcoxon rank sum test data: y by x W = 6, p-value = 0.2 alternative hypothesis: true mu is not equal to 0 (b) wilcox_test tt<-wilcox_test(y~factor(x),distribution="exact") statistic(tt,"linear") 0 12 Jue Wang, Biostatistician Contracted Position for Preclinical & Research Biostatistics PrO Unlimited (908) 231-3022

...,lapply(1:nrow(as.matrix(x)), function(i){ a<-x[i] if (a<0.5){b=0.1} else if (a<1){b=0.3} else if (a<1.5){b=0.5} else if (a<2.5){b=0.7} else if (a<3){b=0.9} else b<-1 }))} xx<-seq(0,3.5,by=0.01) pp<-cdf(xx) plot(xx,pp) Jue Wang, Biostatistician Contracted Position for Preclinical & Research Biostatistics PrO Unlimited (908) 231-3022

...file that looks like group1 group2 Variable 1 Histogram histogram Variable 2 Histogram histogram ........................... Can you give me a hint as to what package I'd look into for help? Thank you Jue Wang, Biostatistician Contracted Position for Preclinical & Research Biostatistics PrO Unlimited (908) 231-3022

If anyone has a list of application areas where there is extensive use of R, I'd like to hear of it. My current short list is: Bioinformatics Epidemiology Geophysics Agriculture and crop science John Maindonald Mathematical Sciences Institute, Australian National University. john.maindonald at anu.edu.au

...on in its Nonclinical Biostatistics group, located in South San Francisco, CA. The nonclinical group currently consists of ten MS and PhD level statisticians and mathematicians, plus one programmer, who work with approximately 1,000 scientists, engineers, and other investigators in drug discovery, preclinical testing, process and product development, manufacturing, and quality control, among other areas - essentially everything but clinical trials. Statistical activities are commensurately diverse. Some "typical" ones are design and analysis of in vitro and in vivo studies exploring efficacy,...

July 14, 2011 Genentech, A Member of the Roche Group, has an opening for a full time position in its nonclinical biostatistics group located in South San Francisco, CA. The nonclinical group consists of statisticians who work with scientists, engineers, and managers in research, drug discovery, preclinical testing, process and product development, manufacturing, and quality control. Statistical activities are commensurately diverse, including: design and analysis of in vitro and in vivo efficacy, pharmacokinetics, toxicity, and ?-omics? studies; statistical support for assay and manufacturing develo...

...erience in medical imaging analysis including design of experiments, image registration and segmentation, statistical analysis, and pattern recognition. The position will initially involve providing statistical, mathematical, and software development support for MRI and ultrasound imaging teams in preclinical research (i.e., animal studies, not human). Merck has its own facilities for CT, PET, MRI, and ultrasound imaging. We are looking for a Ph.D. with a background and/or post-doctoral experience in at least one of the following fields: Statistics, Electrical/Computer or Biomedical Engineering, Comput...

Job description: Computational statistician/biometrician The Biometrics Research Department at Merck Research Laboratories, Merck & Co., Inc. in Rahway, NJ, is seeking a highly motivated statistician/data analyst to work in its basic research, drug discovery, preclinical and early clinical development areas. The applicant should have broad expertise in statistical computing. Experience and/or education relevant to signal processing, image processing, pattern recognition, machine learning, or bioinformatics are preferred. The position will involve providing statisti...

...,0,0.769,0,0.009,0,0,0.798,0.405,0.498,0.946,1.35,1.149,0.528) x<-c(rep(1,10),rep(2,7)) aa<-wilcox.exact(y~x,conf.int=TRUE) bb<-wilcox_test(y~factor(x),distribution="exact",conf.int=TRUE) aa bb Does anyone know why? Thank you Jue Wang, Biostatistician Contracted Position for Preclinical & Research Biostatistics PrO Unlimited (908) 231-3022

...e output window. I would like to use some features in "histogram" from Lattice, but how can I put "histogram" and "densityplot" side by side on the same graph? Thank you par(mfrow=c(2,1)) hist(y) plot(density(y)) Jue Wang, Biostatistician Contracted Position for Preclinical & Research Biostatistics PrO Unlimited (908) 231-3022

The Biometrics Research department at the Merck Research Laboratories has an open position to be located in Rahway, New Jersey, USA: This position will be responsible for imaging and bio-signal biomarkers projects including analysis of preclinical, early clinical, and experimental medicine imaging and EEG data. Responsibilities include all phases of data analysis from processing of raw imaging and EEG data to derivation of endpoints. Part of the responsibilities is development and implementation of novel statistical methods and software for...

...ysis, and interpretation. Applied development of statistical methodology, development of software, and co-authorship of publications and presentations are also primary responsibilities. The scope of the nonclinical statistics group focuses on needs outside traditional clinical trials. This includes preclinical in-vivo, in-vitro, and in-silico studies, as well as product formulations. We also serve experimental medicine needs in clinical pharmacology. A Ph.D. or Masters in statistics or appropriate data-analytic discipline is required. The target candidate is one with approximately 5 years of experience...

...e position is based in the Valley Forge area northwest of Philadelphia, Pennsylvania, in the USA. Extraordinary applicants from outside the US are welcome, subject to visa limitations. The scope of the nonclinical statistics group focuses on needs outside traditional clinical trials. This includes preclinical in-vivo, in-vitro, and in-silico studies, as well as product formulations. We also serve experimental medicine needs in clinical pharmacology. A Ph.D. or Masters in statistics or appropriate data-analytic discipline is required. Comprehensive understanding of linear models is essential. There are...

...ficacy trials. Subsequently, modelling will be used to optimise clinical trial design and characterise the relevance of different clinical trial factors and procedures on study power, bias and treatment effect size. Translational aspects will also be explored to allow better extrapolation from preclinical to clinical findings. The approach is based on hierarchical models and relies on the use of advanced statistical software tools such as NONMEM, WINBUGS and R. We are looking for a highly motivated PhD student or post-doctoral scientist to investigate the research questions indicated above. Thi...

...iscovery and development with a strong focus on priority medicines. Challenges are 1) to develop mechanism-based PKPD models to characterise disease progression and to predict the effects of ageing on clinical response and 2) to create a translational research framework that allows extrapolation of preclinical to clinical and epidemiological findings. Existing (pre-) clinical data will be analysed with advanced data analysis software tools such as NONMEM and R. We are looking for two highly motivated scientists (PhD degree) to: 1) investigate disease models in COPD. The COPD project is part o...

...opening for a fulltime position in its nonclinical biostatistics department, located in South San Francisco, CA. The nonclinical group currently consists of seven MS and PhD level statisticians and mathematicians who work with approximately 800 scientists, engineers, and others in drug discovery, preclinical testing, process and product development, manufacturing, and quality control, among other areas - essentially everything but clinical trials. Statistical activities are commensurately diverse. Some "typical" ones are design and analysis of animal testing for drug efficacy, pharmacokineti...

...working groups have been established which will address the following challenges 1) to develop mechanism-based PK-PD models to characterise disease progression, 2) to predict the effects of ageing on clinical response and 3) to create a translational research framework that allows extrapolation of preclinical to clinical and epidemiological findings. The approach is based on hierarchical models and relies on the use of advanced statistical software tools such as NONMEM, WINBUGS and R. To ensure the development of a conceptual research framework beyond the specific scientific questions being addresse...