R sig jobs - Jul 2009 - Vacancy - PhD / Post-doctoral position at the University of Leiden.

TOP Institute Pharma (TI Pharma) has granted our proposal to set up a 
mechanism-based PKPD modelling platform. This platform focuses on the 
transfer of knowledge from academia to the pharmaceutical industry and is 
a collaborative effort of four excellent academic institutes and six 
leading global pharmaceutical industries. Unique to this platform is the 
availability of shared databases on disease and drug related parameters.

The aim of the platform is to provide a scientific basis for rational drug 
discovery and development with a strong focus on priority medicines. Among 
the various working groups, a research program has been started to 
evaluate biomarkers and disease progression in COPD using longitudinal 
models. The primary scope of this investigation is to establish which 
markers of disease have predictive value for the outcome of efficacy 
trials. Subsequently, modelling will be used to optimise clinical trial 
design and characterise the relevance of different clinical trial factors 
and procedures on study power, bias and treatment effect size. 
Translational aspects will also be explored to allow better extrapolation 
from preclinical to clinical findings. The approach is based on 
hierarchical models and relies on the use of advanced statistical software 
tools such as NONMEM, WINBUGS and R. 

We are looking for a highly motivated PhD student or post-doctoral 
scientist to investigate the research questions indicated above. This 
appointment will be for 2 (post-doctoral fellowship) or 4 years (PhD 
programme) 

Requirements:

The post-doctoral fellow should have the following background and 
competencies: 
A strong background in statistical modelling & simulation and/or Bayesian 
statistics
A degree in Biostatistics, Epidemiology, Medicine,  Biopharmaceutical 
Sciences, Physiology or equivalent scientific training
Bird eyes?  view
Conceptual thinker
Problem-solving and coaching skills are essential
Ambitious
Creative
Interested to perform research in a unique multidisciplinary setting

Organisation 

The Leiden Division of Pharmacology at the Leiden/Amsterdam Center for 
Drug Research (LACDR) has a long-standing expertise in the development of 
Pharmacokinetic/Pharmacodynamic (PKPD) models to predict efficacy and 
safety of drugs.

Conditions of employment 

The employment for this position will be full time for 2 or 4 years.

Additional conditions of employment: You will work as a team member of a 
TI Pharma project. The project team comprises academic and industrial 
partners. In this case, the partners are: University of Leiden, University 
of Groningen, the University Medical Center of Utrecht, the Erasmus 
Medical Center, Rotterdam and the companies Eli Lilly, Johnson &  Johnson, 
GSK, Nycomed, Organon/Schering Plough and Pfizer. You will attend a unique 
drug discovery education and training program offered by TI Pharma.

Additional Information 

Additional information can be obtained through one of the following link: 
http://www.lacdr.nl

Application 
You can apply by sending your application by e-mail to:  Dr. O. Della 
Pasqua, Division of Pharmacology, Leiden/Amsterdam Center for Drug 
Research, Leiden, The Netherlands (odp72514 at gsk.com)
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