R help - Sep 2010 - Getting Error while connecting "R"

Hi, 
This is Krishan, I am working on r-project through vb.Net 
While calling the r-project I got following error

System.Runtime.InteropServices.COMException (0x80040013): Exception from
HRESULT: 0x80040013

at Microsoft.VisualBasic.CompilerServices.LateBinding.InternalLateCall(Object o,
Type objType, String name, Object[] args, String[] paramnames, Boolean[]
CopyBack, Boolean IgnoreReturn)

at Microsoft.VisualBasic.CompilerServices.NewLateBinding.LateCall(Object
Instance, Type Type, String MemberName, Object[] Arguments, String[]
ArgumentNames, Type[] TypeArguments, Boolean[] CopyBack, Boolean IgnoreReturn)

at RSampleApplication.frmSample.btnRAnalysis_Click(Object sender, EventArgs e) 
in D:\Projects\PEMSPLUS\RSampleApplication\RSampleApplication\frmSample.vb:line
23

Can you suggest me  how to solve this error

Best Regards
Krishan